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Poppy did not have cancer. Her grandmother, Helen, had lived another life in the States where her Munchausen, by Proxy, had killed her young son. Martin was a gambling addict and deeply in debt. He concocted the fake illness to get the money and get himself out of trouble. Samantha Greenwood figured it all out, and Martin's son, James, killed Samantha to keep their family secret.
Issy confessed to the murder because she wanted to please the powerful Hayward family.
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